Over the years, we have done a wide range extensive research and clinical trials of YHK on patients with liver diseases.
(including HBV, HCV, Alcoholic Liver disease, dug abuse liver, fatty liver, NASH, cirrhosis and liver cancer.)
You can search for a related research paper here for a better understanding of how YHK can help you to improve liver health.

* All research and clinical data should be used as reference purposes only, results may vary.
All PapersClinical StudiesAward-WinningPublication
01
Hepatitis C

Effect and Application of Yojyo Henshiko

S. Sha 1), N. Yanaihara 2)

Conferences:

16th General Meeting of Medical and Pharmaceutical Society for Wakan-Yaku
28th~29th August 1999 – Makuhari, Japan

02
Hepatitis B
Hepatitis C

Clinical Application and Efficacy of a New Chinese Medical Herb Prescription: “Yojyo Henshiko”

S. Sha 1), N. Yanaihara 2)

Conferences:

2nd Annual Meeting of the Japanese Society for Alternative Medicine & Treatment
10th~11th October 1999 – Yokohama, Japan

03
Hepatitis C

Effect of “Yojyo Henshiko, a new Chinese Herb Prescription”, on Serum ALT and AST Levels in Patients with Hepatic Diseases

S. Sha 1), M.Harada 2), N. Yanaihara 3)

Conferences:

3rd International Conference on Therapies for Viral Hepatitis
12th~16th December 1999 – Maui, Hawai, U.S.A.

IASL-APASL JOINT MEETING 2000
2nd~7th June 2000 – Fukuoka, Japan

04
Liver Protection

Beneficial Effect of a Controlled Chinese Herbal Remedy, K-17.22, in CCL4-Induced Liver Toxicity; an in Vivo and in Vitro Study

F.Marotta 1), A.Rouge 2), H.Anzulovic 2), M.Harada 3), G.M.Ideo 1), K.Kajikawa 4), N.Yanaihara 5), G.Princess 2), G.Ideo 1)

Conferences:

4th JSH International Symposium on Liver Cirrhosis & Liver Cancer; 37th Annual Meeting of Liver Cancer Study Group of Japan
7th~9th June 2001 – Shimonoseki, Japan

European Association for the Study of the Liver
12th~13th October 2001 – Florence, Italy

05
Hepatic Ischemia

Ischemia-Reperfusion Liver Injury: Effect of a Nutritional Approach with K-17.22 on Eudogenous Hepatic Antioxidant System

F.Marotta 1), G.M.Ideo 1), MG Seal 2), CC Wu 3), P Safran 2), M.Harada 4), N. Yanaihara 4), G.Ideo 1)

Conferences:

4th JSH International Symposium on Liver Cirrhosis & Liver Cancer; 37th Annual Meeting of Liver Cancer Study Group of Japan
6th~9th June 2001 – Shimonoseki, Japan

06
Chronic Pancreatitis

A Nutritional Approach with Herbal Remedy K-17.22 Delays the Onset of Spontaneous Chronic Pancreatitis

F.Marotta 1), M.Harada 2), MG Seal 2), J.Bertuccelli 3), A.Rouge 3), H.Anzulovic 3), N.Yanaihara 4), G.Ideo 1)

Conferences:

25th National Congress of the Italian Association of Pancreatology Study
20th~22nd June 2001 – Como, Italy

07
Hepatitis C
Hepatic Ischemia

Effect of a Nutritional Approach with K-17.22 on Endogenous Hepatic Antioxidant System

F.Marotta, M. Harada, N. Yanaihara, G.M. Ideo, MG Seal, CC Wu, P Safran, G.Ideo

Conferences:

European Association for the Study of the Liver
12th~13th October 2001 – Florence, Italy

08
Hepatitis C

The Effect of the Yojyo Hen Shi Ko for the liver diseases -Specially for the Hepatitis Type C

M.Harada, N.Yanaihara, F.Marotta, I.Yoshijima, H.Shimizu, K.Hosokawa, Y.Tsuji, Y.Harada, S.Sha

Conferences:

The 43th The Journal of All Japan Hospital Association
20th October 2001 – Saitama, Japan

09
Hepatitis B
Hepatitis C
Cirrhosis
Liver Cancer
Fatty Liver

The Effect of the Tablets

S. Sha 1), M. Harada 2), N. Yanaihara 3)

Conferences:

The 4th Annual Meeting of the Japanese Society for Alternative Medicine and Treatment
10th~11th November 2001 – Osaka, Japan

10
Hepatitis B
Hepatitis C
Cirrhosis
Liver Cancer
Fatty Liver

Effect of “Yojyo Henshiko (YHK)”, in Patients with Hepatic Diseases

S. Sha 1), M. Harada 2), N. Yanaihara 3)

Conferences:

HEP DART 2001
16th~20th December 2001 – Maui, Hawai, U.S.A.

11
Hepatitis C
Liver Cancer

Effect of K-17.22, a Novel Phytoterapeutic Agent, on DNA Synthesis and Liver Enzyme Release in Experimental Liver Damage

F.Marotta 1), 2 YR-Shield 2), E.Minelli 3), A.Helmy 4), P.Safran 2), M.Harada 5)

Conferences:

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

12
Liver Fibrosis

Is There Any Liver Anti-Fibrotic Effect of K-17.22? An Experimental Study with Immunohistochemical Analysis in A Rat Model

F.Marotta 1), 2 YR-Shield 2), E.Minelli 3), E. Oliva 4), P.Safran 2), M.Harada 5)

Conferences:

First JSH Single Topic Conference
14th~15th November 2002 – Yamanashi, Japan

14
Hepatitis C

Effect of a Novel Phytoterapeutic on DNA Synthesis and Enzyme Release In Experimental Liver Damage

F.Marotta 1), YR-Shield 2), E.Minelli 3), A Helmy 4), P.Safran 2)

Conferences:

First National Herb and Spice Conference: Grassroots to Global Enterprise
18th~19th February 2004 – Ontario, Canada

15

For “Shining of Life Force”-Basics & Potential Contribution of Yojyo Foods

S. Sha

Conferences:

First National Herb and Spice Conference: Grassroots to Global Enterprise
18th~19th February 2004 – Ontario, Canada

16

An In Vitro Study on the Beneficial Effect of YHK, A Natural Herbal Compound, on Metal-Induced Oxidative Damage of Hepatocytes and Mithocondrial Fraction

F.Marotta 1), P.LeCroix 2), M.Harada 3), K.Masulair 4), C.Turnes 2), P.Safran 3), E.Fesce 1)

Conferences:

7th International ISSX Meeting
29th August~2nd September 2004 – Vancouver, Canada

17
Hepatitis C
Hepatic Ischemia
Liver Cancer
Liver Fibrosis

Herbal Products for Liver Disease: A Therapeutic Challenge for the New Millenium

F.Marotta

Conferences:

Hiroshima University M.D. Lecture Presentation
4th October 2004 – Hiroshima, Japan

18
NASH

Exploring Strategies to Treat NASH: Beneficial Effect of YHK on Metal-Induced Oxidative Damage of Hepatocytes and Lysosomal Fraction

F.Marotta, P.LeCroix, M.Harada, K.Masulair, C.Turnes, L.Mondazzi, P.Safran, E.Fesce

Conferences:

Third JSH Single Topic Conference
7th~8th October 2004 – Kochi, Japan

4th World Congress on Trauma, Sjock, Inflammation and Sepsis – Pathophysiology, Immune Consequences and Therapy
4th November 2004 – Munich, Germany

2nd Natural Health Product Conference
11th~13th February 2005 – Vancouver, Canada

19
Hepatitis C

Integrative Medicine in the III Millenium: Herbal Products for Liver Disease

F. Marotta, E. Minelli, U. Solimene, SH Sha.

Conferences:

Saudi Gastroenterology Association
10th November~2nd December 2004 – Saudi Arabia

20

Herbal Products for Liver Disease

Conferences:

Asian Pacific Association for the Study of the Liver(APASL) Conference 2004
11th December 2004~15th January 2005 – New Delhi, India

21
Liver Protection
Anti Ageing

Liver Exposure to Xenobiotics: The Aging Factor and Potentials for Functional Foods

F. MAROTTA, P. LECROIX, M. HARADA, K. MASULAIR, P. SAFRAN, A. LORENZETTI, SK ONO-NITA, and P. MARANDOLA

Publication:

REJUVENATION RESEARCH Volume 9, Number 2, 2006

22
NASH

Yo Jyo Hen Shi Ko (YHK) Improves Transaminases in Nonalcoholic Steatohepatitis(NASH): A Randomized Pilot Study

Nilesh Chande, Maggie Laidlaw, Paul Adams, Paul Marotta

Conferences:

1st Annual Canadian Association for the Study of the Liver
Winter Meeting: Updates in Hepatology
19th~22nd March 2005 – Canada

Publication:

Digestive Diseases and Sciences 2006

23
Liver Cancer

Carcinogen-Metabolizing Enzyme Activity in the Liver: Beneficial Effect of the Phytotherapeutic Compound YHK

F. Marotta 1), P. LeCroix 2), M. Harada 3), K. Masulair 4), P. Safran 3), E. Fesce 1)

Conferences:

8th World Congress on Gastrointestinal Cancer
28th June~1st July 2006 – Barcelona, Spain

24
NASH

Nonalcoholic Steatohepatitis (NASH) in OB/OB Mice Treated with Yo Jyo Hen Shi Ko (YHK): Effects on Peroxisome Proliferator-Activated Receptors (PPARs) and Microsomal Triglyceride Transfer Protein (MTP)

J. T. Stefano, C. P. M. S. de Oliveira, M. L. Correˆa-Giannella, V. M. R. de Lima, S. V. de Sa, E. P. de Oliveira, E. S. de Mello, D. Giannella-Neto, V. A. F. Alves, F. J. Carrilho

Publication:

Digestive Diseases and Sciences Vol.52, 2007

25
NASH

YHK(YojyoHenshiKo), a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine-choline-deficient diet

Lima V.M.1, Oliveira C.P 1), Sawada L.Y 1), Barbeiro H.V 2), Mello E.S 3), Soriano F.G 2), Alves V.A.F 3), Caldwell S.H 4), Carrilho F.J 1)

Publication:

“Liver International” Volume 27, Issue2

26
Liver Cancer

In vitro study on the mechanisms of action of a novel phytotherapeutic compound against human hepatoma cells

F Marotta;1,3 M Harada;2 KL Goh;3 A Lorenzetti;4 P Marandola;4 E Minelli 1

Publication:

Annals of Hepatology
1st April 2007

27
Liver Cancer

Phytotherapeutic compound YHK exerts an inhibitory effect on early stage of experimentally-induced neoplastic liver lesions

Marotta F;1,4 Harada M;2 Goh KL;3 Lorenzetti A;1 Gelosa F;1 Minelli E4

Conferences:

International Symposium on: Functional Foods in Europe – International Developments in Science and Health Claims
9th~11th May 2007 – St Julian’s, Malta

American Institute for Cancer Research (AICR) Annual Conference on Food, Nutrition, Physical Activity and Cancer
6th~7th November 2008 – Washington DC, U.S.A.

Publication:

Annals of Hepatology 2006

30
Liver Cancer

Yo Jyo Hen Shi Ko (YHK) Modulates the Expression of Proteins Involved in de novo Lipogenesis and Lipid Exportation in Experimental Nonalcoholic Steatohepatitis (NASH)

I. Pereira, C. de Oliveira, J. Stefano, V. Debas, N. Halla, J. Alves, F. Laurindo, F. Carrilho

Publication:

Journal of Pharmacy and Nutrition Science 2013

32
Liver Protection

A study of Chinese Medical herb prescription prevents Chronic and other liver disease

1 S.Sha, 2 O.Yamamoto, 3 M.Harada, 4 F.Marotta

Conferences:

The 16th Annual Meeting of the Japanese Society for Complementary and Alternative Medicine
30 Nov~1 Dec May 2013 – Kanazawa, Japan

33
Neuron

Biological evaluations of DTS and YHK on neuronal differentiation in PC12 cell model

Center for Chinese Medicine R&D - By a University located in Hong Kong

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